Economic development, social media awareness, and technological innovation in biogas sector under climate change in the post-COVID-19 pandemic conditions.

After COVID-19, financing for emerging nation reserves in renewable energy bases was deemed a crucial aspect of sustainable development. Investing in biogas energy plants can be highly beneficial for lowering the use of fossil fuels. Using a survey of shareholders, investors, biogas energy professionals, and active social media participants in Pakistan, this study evaluates the intentions of individual investors to invest in biogas energy plants. The primary purpose of this study is to increase investment intent for biogas energy projects following COVID-19. This study focuses on financing biogas energy plants in the post-COVID-19 era and evaluates the research's assumptions using partial least squares structural equation modeling (PLS-SEM). The study employed the technique of purposive sampling to acquire data for this investigation. The results indicate that attitudes, perceived biogas energy benefits, perceived investment attitudes, and supervisory structure evaluations inspire one's propensity to finance biogas vitality plant efforts. The study found a link between eco-friendly responsiveness, monetary benefits, and investors' actions. The aspiration of investors to mark such reserves was set up to be unpretentious by their risk aversion. Conferring to the facts, evaluating the monitoring structure is the critical factor. The previous studies on investment behavior and other forms of pro-environmental intent and action yielded contradictory results. In addition, the regulatory environment was evaluated to see how the theory of planned behavior (TPB) affects financiers' objectives to participate in biogas power plants. The consequences of the study indicate that feelings of pride and discernment of energy expansively affect people's desire to invest in biogas plants. Biogas energy efficacy has little effect on investors' decisions to invest in biogas energy plants. This study offers policymakers practical ideas on enhancing investments in biogas energy plants.

"Crisis" or "opportunity"? COVID-19 pandemic's impact on environmentally sound invention efficiency in China.

Introduction: The environmentally sound invention (ESI) is a "bridge" between environmental sound technologies (ESTs) and green productions. This study investigates the COVID-19 pandemic's impact on ESI efficiency using a multi-methods model in three stages. Methods: The ESI efficiency is measured using the Slack-Based Measure (SBM) method in the first stage. By excluding the environmental effect of the pandemic on each province using the stochastic frontier analysis (SFA) model's results in the second stage, this study compares the ESI efficiency change with or without the influence of the pandemic in the third stage. Results: The results show that the pandemic can be a "crisis" in the short term, but an "opportunity" in the long term. First, the SBM efficiency results in the first stage show a decrease in the number of the average efficient provinces in which the pandemic is more severe during 2020-2021. Second, results of the spatial Tobit and SFA models provide evidence that the COVID-19 pandemic negatively impacts the ESI efficiency during 2020, this impact is decreasing in 2021, and this impact has a spatial diffusion effect. Discussion: Based on these results, this study discussed the theoretical and political implications. This paper enriches the knowledge of ESTs research and development by proposing a three-stage approach with multi-methods to investigate the influence of the pandemic's impact on ESI efficiency.

A Decade of Scientific and Technological Innovation at Chinese Academy of Medical Sciences & Peking Union Medical College: Retrospect and Prospect.

Focusing on the reform initiatives of Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) in medical scientific and technological innovation from perspectives of deepening the reform and optimizing the ecosystem of science and technology innovation, this article summarizes the highlights of CAMS & PUMC's efforts in safeguarding people's health and promoting the Healthy China 2030 strategy through scientific and technological innovation in the fields including basic research, disease prevention and treatment, and medical technology in the past ten years. These achievements embody the endeavors and responsibility of CAMS & PUMC in realizing self-reliance and self-improvement of Chinese medical science and technology and highlight its contributions to the development of medical science and technology of China.

From research to market: correlation between publications, patent filings, and investments in development and production of technological innovations in biosensors.

As the global population grows and science and technology development evolve, fulfilling basic human needs has been even more linked to technological solutions. In this review, we present an overview of the biosensor market and discuss the factors that make certain countries more competitive than others in terms of technology and innovation and how this is reflected in the trends in publication and patent filling. Additionally, we expose briefly how the COVID-19 pandemic acts as a catalyst for the integration of research and development, business, and innovation sectors to bring solutions and ideas that have been predicted as tendencies for the future.

Analyzing the ecological relations of technology innovation of the Chinese high-tech industry based on the Lotka-Volterra model.

Technology innovation has become an important driving force of economic and social development and has received wide attention from academics. Most scholars mainly take technology innovation as an overall variable to explore its impact on the economy and society. The main contribution of this study is to open the black box of technology innovation and introduce the lotka-Volterra model to explore the internal structure of technology innovation in the Chinese high-tech industry and to analyze the ecological relationships, evolutionary trends, equilibrium states of six technology innovation species including independent innovation (II), technology import (TI), research & development (RD), technology renovation (TR), foreign technology acquisition (FTA), and domestic technology purchase (DTP). The results of the study show that, First, the ecological relationship between prey and predator is observed between RD and TR, DTP and FTA, and II and TI. Second, no equilibrium state is observed between TD and TF and II and TI. Third, an unstable equilibrium state is observed between RD and TR.

Mechanism of High-Tech Enterprises' Technological Practices Affected by the Split Fault of Knowledge Innovation Network.

Knowledge innovation ability is the source of value realization of high-tech enterprises, and the acquisition of high-value knowledge is important. Taking knowledge as the intermediary variable, knowledge field activity and knowledge fermentation as mediating variables, and knowledge mobilization and knowledge network position transition as moderating variables, the conceptual model and theoretical analysis framework of the impact mechanism of knowledge innovation network fragmentation fault on technology practices is constructed and the moderated mediating effect model is derived. Taking high-tech enterprises as empirical samples, 538 valid questionnaires were obtained online and offline and the nonpercentile bootstrap method based on deviation correction was used to empirically investigate the influence mechanism and transmission path of knowledge innovation network fragmentation fault on high-tech enterprises' technological practices. The empirical results show that the main effect of knowledge innovation network fragmentation fault on high-tech enterprise technology practices is significant. Knowledge field activity and knowledge fermentation play a differential mediating role in knowledge innovation network split fault and Technology Convention. Knowledge field activity and knowledge fermentation play a partial mediating role in knowledge innovation network split fault and Technology Convention. Knowledge mobilization partially moderates the split fault of knowledge innovation network and technological practices. Knowledge mobilization positively moderates the positive effect of split fault of knowledge innovation network on technological practices and significantly positively moderates the mediating effect of knowledge field activity and knowledge fermentation, resulting in the moderated mediating effect. Knowledge network location transition plays a part of moderating role in knowledge innovation network split fault and Technology Convention. Knowledge network location transition positively moderates the positive impact of knowledge innovation network split fault on Technology Convention and significantly positively moderates the mediating role of knowledge field activity and knowledge fermentation, resulting in a moderated mediating effect. Knowledge innovation network split fault, knowledge field activity and knowledge fermentation, knowledge mobilization and knowledge network location transition, and the combination of technological practices can be the antecedents of promoting technological practices in high-tech enterprises. Through the research on the mechanism of knowledge innovation network split fault in the technological practices of high-tech enterprises, the connotation of knowledge innovation network split fault is enriched, the influencing factors of technological practices are clarified, and the value-added knowledge is promoted and has guiding and reference significance for the innovation knowledge acquisition and competitiveness improvement of high-tech enterprises.

Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature.

COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sativa L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19 potential, clinical trials, inventions, and patent literature related to NS and its major chemical constituents, like thymoquinone. The literature was collected from different databases, including Pubmed, Espacenet, and Patentscope. The literature supports the efficacy of NS, NS oil (NSO), and its chemical constituents against COVID-19. The clinical data imply that NS and NSO can prevent and treat COVID-19 patients with a faster recovery rate. Several inventions comprising NS and NSO have been claimed in patent applications to prevent/treat COVID-19. The patent literature cites NS as an immunomodulator, antioxidant, anti-inflammatory, a source of anti-SARS-CoV-2 compounds, and a plant having protective effects on the lungs. The available facts indicate that NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to prevent, manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a combination therapy. Many compositions of NS in combination with countless medicinal herbs and medicines are still unexplored. Accordingly, the authors foresee a bright scope in developing NS-based anti-COVID-19 composition for clinical use in the future.

Preprint servers and patent prior art: Preprints can jeopardize the patentability of an invention: Preprints can jeopardize the patentability of an invention.

Posting papers on preprint servers creates patent 'prior art' and is likely to affect the patentability of any underlying invention.

Artificial intelligence in orthopaedics surgery: transforming technological innovation in patient care and surgical training.

Artificial intelligence (AI) is an exciting field combining computer science with robust data sets to facilitate problem-solving. It has the potential to transform education, practice and delivery of healthcare especially in orthopaedics. This review article outlines some of the already used AI pathways as well as recent technological advances in orthopaedics. Additionally, this article further explains how potentially these two entities could be combined in the future to improve surgical education, training and ultimately patient care and outcomes.

Development of Therapeutic and Prophylactic Zinc Compositions for Use against COVID-19: A Glimpse of the Trends, Inventions, and Patents.

Zinc is an essential nutrient for human health; it is involved in the catalytic, structural, and regulatory functions of the human cellular system. Different compositions of zinc, as well as its pharmaceutically acceptable salts, are available on the market. Recent studies have demonstrated the role of zinc in combating COVID-19. It has been determined that zinc prevents the entry of SARS-CoV-2 into cells by lowering the expression of ACE-2 receptors and inhibiting the RNA-dependent RNA polymerase of SARS-CoV-2. Zinc also prevents the cytokine storm that takes place after the entry of SARS-CoV-2 into the cell, via its anti-inflammatory activity. The authors believe that no study has yet been published that has reviewed the trends, inventions, and patent literature of zinc compositions to treat/prevent COVID-19. Accordingly, this review has been written in order to fill this gap in the literature. The information about the clinical studies and the published patents/patent applications was retrieved from different databases. This review covers patent literature on zinc compositions up to 31 January 2022. Many important patents/patent applications for zinc-based compositions filed by innovative universities and industries were identified. The patent literature revealed zinc compositions in combination with zinc ionophores, antioxidants, antivirals, antibiotics, hydroxychloroquine, heparin, ivermectin, and copper. Most of these studies were supported by clinical trials. The patent literature supports the potential of zinc and its pharmaceutical compositions as possible treatments for COVID-19. The authors believe that countless zinc-based compositions are still unexplored, and there is an immense opportunity to evaluate a considerable number of the zinc-based compositions for use against COVID-19.

Evolutionary Path and Innovative Development of Pharmaceutical Industrial Cluster-A Case Study of Shijiazhuang, China.

The innovation and development practices of the pharmaceutical industry are of great importance for the continual enhancement of public health. Industrial clusters are one of the important means by which the pharmaceutical industry can be transformed and developed, but there is a lack of research on the evolutionary path and development innovation of pharmaceutical industrial clusters. As a country with a major pharmaceutical industry, the transformation and development path of traditional pharmaceutical industrial clusters in China has important reference value for the sustainable development of the global pharmaceutical industry. Through an analysis of the evolution of traditional pharmaceutical industrial clusters in Shijiazhuang, this study explores the law of the dynamic evolution of pharmaceutical industrial clusters and the associated mechanisms. Specifically, we conclude that the evolutionary path of traditional pharmaceutical industrial clusters can be divided into the government-led pharmaceutical industrial cluster start-up stage, the government-guided pharmaceutical industrial cluster development stage, and the government-served pharmaceutical industrial cluster transformation stage. The operating mechanisms include a self-organization mechanism, an innovation-driven mechanism, and an outward associated mechanism, each of which plays different roles in the different stages of the dynamic evolution of the cluster, and the synergistic operation of the three mechanisms forms an important basis for the evolution of pharmaceutical industrial clusters. We found that the innovation development of traditional pharmaceutical industrial clusters is influenced by the synergy of the self-organization, innovation-driven, and outward associated mechanisms. The self-organization mechanism is a necessary condition for pharmaceutical industrial clusters to realize the transition from disorder to order. The innovation-driven mechanism is the core driving force for the innovative development of pharmaceutical industrial clusters. Finally, the outward associated mechanism is the main means by which pharmaceutical industrial clusters integrate into the global value chain.

Moving Towards Equity With Digital Health Innovations for Stroke Care.

Digital health has long been championed as a means to expanding access to health care. Now that the COVID-19 pandemic accelerated many health systems' integration of digital tools for care, digital health may provide a path towards more accessible stroke prevention and treatment, particularly for historically disadvantaged patient populations. Stroke management is composed of multiple time points where digital health innovations have the potential to augment health access and treatment: from primary prevention, to the time-sensitive detection of ischemic stroke, administration of thrombolytic agents and consideration for endovascular interventions, to appropriate post-acute care, rehabilitation, and lifelong secondary stroke prevention-stroke care relies on a multidisciplinary and standardized approach. However, as we discuss pointedly in this Focused Update, underrepresented individuals face multilevel digital health disparities that potentially diminish the benefits of these digital advances. As such, these multilevel needs must be discussed and accounted for as health systems seek to integrate innovative and equitable digital health solutions towards stroke care.